Mrs. Edwards, 57, was first diagnosed with cancer in the final weeks of the 2004 campaign. The day after Democratic presidential nominee John Kerry and Edwards, his running mate, conceded the election to George W. Bush, Edwards announced that his wife had invasive ductal cancer, the most common type of breast cancer, and would undergo treatment.
Mrs. Edwards underwent several months of radiation and chemotherapy for the lump in her breast. Her husband's campaign has said she had recovered from the illness.
``I don't look sickly, I don't feel sickly. I am as ready as any person can be for that,'' she said at the news conference.
John Edwards said a biopsy of her rib had showed that the cancer had returned.
The bone is one of the most common places where breast cancer spreads, and once it does so it is not considered curable.
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